Case 4: AML with t(8;21)

Case 4: AML with t(8;21)

A single, thin, tapered Auer rod is classic for AML with t(8;21)

Other key points:

There is an association with systemic mastocytosis in approximately 10% of cases

RUNX1::RUNX1T1 is associated with the 8;21 translocation

This fusion protein blocks transcription of genes involved in hematopoietic differentiation

The prognosis of AML with t(8;21) RUNX1::RUNX1T1 is favorable. Although, the presence of additional mutations (such as KIT) can be associated with poorer prognosis

Find this case on Twitter: