This is AML w/ t(6;9). Can be a/w basophilia, but not always (couldn’t find in this case)
AML with t(6;9) is strongly associated with another genetic abnormality....
AML w/ t(6;9) is strongly associated with FLT3-ITD
FLT3-ITD can also be a/w other AML subtypes. Prognostic impact varies based on underlying cytogenetics:
- No impact on prognosis of AML w/ t(6;9) (already has poor prognosis) or t(15;17)
- Worse prognosis in AML w/ NPM1
FLT3 is a tyrosine kinase. Mutations occur in approximately 1/3 of patients with AML, often as internal tandem duplications (ITD) 👯♀️ These are in-frame duplications of 3 to >400 base pairs.
The next most common is a point mutation in D835
How can these be detected? 🤔
Fluorescent-labeled PCR-based assay ➡️ capillary electrophoresis to analyze fragment length
Why is this important?
In some subgroups of AML, ✨testing for FLT3 ITD in AML is important for prognosis (as stated above) & for guiding treatment (FLT3-targeted therapy)✨
See an excellent review here ⬇️:
That’s all! Thanks for following along 🤗
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